Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent

Behav Brain Res. 2015 Jul 15:288:103-6. doi: 10.1016/j.bbr.2015.04.001. Epub 2015 Apr 9.

Abstract

GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic. Interestingly, the control that adenosine A2A receptor exerted over TJMs was lost in the absence of GPR37, thus pointing to a pivotal role of this orphan receptor in the adenosinergic control of parkinsonian tremor.

Keywords: GPR37; Orphan receptor; Pael-R; Parkinson's disease; Tremulous jaw movement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine A2 Receptor Antagonists / pharmacology
  • Animals
  • Jaw / drug effects
  • Jaw / physiopathology*
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Movement / drug effects
  • Movement / physiology
  • Muscarinic Antagonists / pharmacology
  • Parkinsonian Disorders / drug therapy
  • Parkinsonian Disorders / physiopathology*
  • Pilocarpine
  • Pyrimidines / pharmacology
  • Receptor, Adenosine A2A / metabolism*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Tremor / drug therapy
  • Tremor / physiopathology*
  • Triazoles / pharmacology
  • Tropicamide / pharmacology

Substances

  • 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine
  • Adenosine A2 Receptor Antagonists
  • Gpr37 protein, mouse
  • Muscarinic Antagonists
  • Pyrimidines
  • Receptor, Adenosine A2A
  • Receptors, G-Protein-Coupled
  • Triazoles
  • Pilocarpine
  • Tropicamide