Minor Prenylated Flavonoids from the Twigs of Macarangaadenantha and Their Cytotoxic Activity

Da-Song Yang; Shuang-Mei Wang; Wei-Bing Peng; Yong-Ping Yang; Ke-Chun Liu; Xiao-Li Li; Wei-Lie Xiao

doi:10.1007/s13659-015-0059-1

Minor Prenylated Flavonoids from the Twigs of Macarangaadenantha and Their Cytotoxic Activity

Nat Prod Bioprospect. 2015 Apr 10;5(2):105-109. doi: 10.1007/s13659-015-0059-1. eCollection 2015 Apr.

Authors

Da-Song Yang^#¹, Shuang-Mei Wang^#¹, Wei-Bing Peng², Yong-Ping Yang¹, Ke-Chun Liu², Xiao-Li Li¹, Wei-Lie Xiao³

Affiliations

¹ Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
² Biology Institute of Shandong Academy of Sciences, Jinan, 250014 People's Republic of China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.

^# Contributed equally.

Abstract

Three new minor prenylated flavonoids, named macadenanthins A-C (1-3), together with three known ones (4-6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1-3 were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC₅₀ values in the range of 13.76-22.27 μM.

Keywords: Cytotoxicity; Macadenanthins A–C; Macaranga adenantha; Prenylated Flavonoids.