Abstract
A solid-phase synthesis for nucleic acid-polymer amphiphiles is developed. Using this strategy, several DNA-b-polymer amphiphiles are synthesized, and their self-assembly in aqueous solution is investigated. This general method can in principle be extended to nearly all polymers synthesized by atom transfer radical polymerization to produce a variety of nucleic acid-polymer conjugates.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Kinetics
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Molecular Structure
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Nucleic Acids / chemical synthesis
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Nucleic Acids / chemistry*
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Particle Size
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Polymers / chemical synthesis
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Polymers / chemistry*
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Surface Properties
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Surface-Active Agents / chemical synthesis*
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Surface-Active Agents / chemistry
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Thermodynamics
Substances
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Nucleic Acids
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Polymers
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Surface-Active Agents