Facile synthesis of nucleic acid-polymer amphiphiles and their self-assembly

Chem Commun (Camb). 2015 May 7;51(37):7843-6. doi: 10.1039/c5cc01934f.

Abstract

A solid-phase synthesis for nucleic acid-polymer amphiphiles is developed. Using this strategy, several DNA-b-polymer amphiphiles are synthesized, and their self-assembly in aqueous solution is investigated. This general method can in principle be extended to nearly all polymers synthesized by atom transfer radical polymerization to produce a variety of nucleic acid-polymer conjugates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Kinetics
  • Molecular Structure
  • Nucleic Acids / chemical synthesis
  • Nucleic Acids / chemistry*
  • Particle Size
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Surface Properties
  • Surface-Active Agents / chemical synthesis*
  • Surface-Active Agents / chemistry
  • Thermodynamics

Substances

  • Nucleic Acids
  • Polymers
  • Surface-Active Agents