Abstract
Bacillus subtilis subsp. natto produces poly-γ-glutamic acid under the control of quorum sensing. We identified ComXnatto pheromone as the quorum-sensing pheromone with an amino acid sequence of Lys-Trp-Pro-Pro-Ile-Glu and the tryptophan residue posttranslationally modified by a farnesyl group. ComXnatto pheromone is unique in the sense that the 5th tryptophan residue from the C-terminal is farnesylated.
Keywords:
Bacillus subtilis; isoprenylation; posttranslational modification; quorum sensing; tryptophan.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacillus subtilis / genetics
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Bacillus subtilis / metabolism*
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Molecular Sequence Data
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Pheromones / chemistry
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Pheromones / genetics
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Pheromones / metabolism*
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Polyglutamic Acid / biosynthesis
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Prenylation
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Protein Processing, Post-Translational*
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Protein Structure, Tertiary
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Quorum Sensing / genetics*
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Tryptophan / metabolism*
Substances
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Bacterial Proteins
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Pheromones
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Polyglutamic Acid
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Tryptophan