Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours

Eva Tsouana; Sara Stoneham; Naomi Fersht; Neil Kitchen; Mark Gaze; Jamshed Bomanji; Francesco Fraioli; Darren Hargrave; Ananth Shankar

doi:10.1002/pbc.25538

Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours

Pediatr Blood Cancer. 2015 Sep;62(9):1661-3. doi: 10.1002/pbc.25538. Epub 2015 Apr 8.

Authors

Eva Tsouana¹, Sara Stoneham¹, Naomi Fersht², Neil Kitchen³, Mark Gaze², Jamshed Bomanji⁴, Francesco Fraioli⁴, Darren Hargrave⁵, Ananth Shankar¹

Affiliations

¹ Department of Pediatric & Adolescent Oncology, University College London Hospitals NHS Foundation Trust, UK.
² Department of Oncology, University College London Hospitals NHS Foundation Trust, UK.
³ Department of Neurosurgery, University College London Hospitals NHS Foundation Trust, UK.
⁴ Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, UK.
⁵ Department of Pediatric Oncology, Great Ormond Street Hospital, UK.

PMID: 25854508
DOI: 10.1002/pbc.25538

Abstract

The efficacy of hybrid 18F-Fluroethyl-Choline (FEC) positron emission tomography (PET)/magnetic resonance imaging (MRI) was investigated as an imaging modality for diagnosis and assessment of treatment response and remission status in four patients with proven or suspected intracranial non-germinomatous germ cell tumours (NGGCT). In two patients faint or absent choline avidity correlated with negative histology, whereas in other two patients, persistent choline avidity in the residual mass was suggestive of presence of viable tumour, subsequently confirmed histologically. We conclude that FEC-PET/MRI may be an effective imaging tool in detecting viable residual tumour in patients with intracranial NGGCT post treatment.

Keywords: 18F-fluoroethyl-choline; PET; choline; intracranial germ cell tumours; neuro-oncolgy; positron emission tomography.

Publication types

Case Reports
Evaluation Study

MeSH terms

Adolescent
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biomarkers, Tumor / blood
Brain Neoplasms / diagnostic imaging*
Brain Neoplasms / therapy
Cerebral Ventricle Neoplasms / diagnostic imaging*
Cerebral Ventricle Neoplasms / therapy
Choline / analogs & derivatives
Combined Modality Therapy
Cranial Irradiation
Craniotomy
Female
Fluorine Radioisotopes
Humans
Magnetic Resonance Imaging*
Male
Multimodal Imaging
Neoplasms, Germ Cell and Embryonal / diagnostic imaging*
Neoplasms, Germ Cell and Embryonal / therapy
Neuroimaging / methods*
Pineal Gland / diagnostic imaging
Pinealoma / diagnostic imaging*
Pinealoma / therapy
Positron-Emission Tomography*
Radiopharmaceuticals
Young Adult

Substances

Biomarkers, Tumor
Fluorine Radioisotopes
Radiopharmaceuticals
fluorocholine
Choline