Abstract
Sesterterpenes with a salmahyrtisane skeleton have been synthesized for the first time. (-)-Sclareol has been selected as a precursor for the synthesis of two novel natural products: salmahyrtisol A (1) and hippospongide A (2). Our results represent a biomimetic approach to obtaining salmahyrtisanes from hyrtiosanes. Salmahyrtisol A has shown an activity comparable to that of the standard anticancer drugs in the cell lines A549, HBL-100, HeLa, and SW1573.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Biomimetic Materials / chemical synthesis
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Biomimetic Materials / chemistry
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Biomimetic Materials / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Molecular Conformation
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Sesterterpenes / chemical synthesis
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Sesterterpenes / chemistry
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Sesterterpenes / pharmacology*
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Stereoisomerism
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Structure-Activity Relationship
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Terpenes / chemical synthesis
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Terpenes / chemistry
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Terpenes / pharmacology*
Substances
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Antineoplastic Agents
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Sesterterpenes
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Terpenes
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hippospongide A
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salmahyrtisol A