Cardiac resynchronisation therapy in 2015: keeping up with the pace

Intern Med J. 2016 Mar;46(3):255-65. doi: 10.1111/imj.12774.

Abstract

Despite improved understanding of the pathophysiology of heart failure (HF) and availability of better medical therapies, HF continues to grow as a cause of morbidity and mortality in Australia and worldwide. Over the past decade, cardiac resynchronisation therapy (CRT), or biventricular pacing, has been embraced as a powerful weapon against this growing epidemic. However, much has changed in our understanding of dyssynchrony in HF, and this has led to a change in guidelines to ensure more appropriate selection of CRT candidates to improve the 'non-response' rate. More data have also emerged about the use of CRT in atrial fibrillation and in pacemaker-dependent patients. There has also been a growing focus on multimodality imaging to guide patient selection and lead positioning. Exciting new lead technologies are also emerging, with the potential to improve CRT outcomes further.

Keywords: biventricular pacing; cardiac resynchronisation therapy; dyssynchrony; heart failure.

Publication types

  • Review

MeSH terms

  • Australia / epidemiology
  • Cardiac Resynchronization Therapy / methods*
  • Cardiac Resynchronization Therapy / trends
  • Heart Failure / diagnosis
  • Heart Failure / epidemiology
  • Heart Failure / therapy*
  • Humans
  • Pacemaker, Artificial* / trends
  • Randomized Controlled Trials as Topic / methods