An intramolecular crossed-benzoin reaction based KCN fluorescent probe in aqueous and biological environments

Chem Commun (Camb). 2015 May 4;51(36):7709-12. doi: 10.1039/c5cc02234g.

Abstract

A turn-on fluorescent probe was designed for selective cyanide anion sensing in aqueous and biological environments. The probe underwent an intramolecular crossed-benzoin reaction in the presence of KCN to expel the fluorophore resorufin. This probe was sensitive to KCN concentrations as low as 4 nM in aqueous media.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anions / analysis
  • Benzoin / chemistry*
  • Cyanides / analysis*
  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Microscopy, Confocal
  • Molecular Structure
  • Oxazines / chemistry
  • Potassium Cyanide / analysis*
  • Spectrometry, Fluorescence
  • Water / chemistry

Substances

  • Anions
  • Cyanides
  • Fluorescent Dyes
  • Oxazines
  • Water
  • resorufin
  • Benzoin
  • Potassium Cyanide