Abstract
This survey on steroidal alkaloids of the Veratrum and Solanum family isolated between 1974 and 2014 includes 187 compounds and 197 references. New developments in the chemistry and biology of this family of natural products with a special focus on the medicinal relevance of the jervanine alkaloid cyclopamine are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Diosgenin / chemistry
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Diosgenin / pharmacology
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Humans
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Molecular Structure
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Solanaceous Alkaloids / chemistry*
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Solanaceous Alkaloids / pharmacology*
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Veratrum Alkaloids / chemistry*
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Veratrum Alkaloids / isolation & purification
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Veratrum Alkaloids / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Solanaceous Alkaloids
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Veratrum Alkaloids
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verazine
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Diosgenin
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veratramine
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solanidine
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cyclopamine