Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements

Yoshinori Aoki; Daisuke Nishizawa; Junko Hasegawa; Shinya Kasai; Kaori Yoshida; Yoshihiko Koukita; Tatsuya Ichinohe; Makoto Nagashima; Ryoji Katoh; Yasuo Satoh; Megumi Tagami; Masakazu Hayashida; Ken-ichi Fukuda; Kazutaka Ikeda

doi:10.1016/j.jphs.2015.02.005

Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements

J Pharmacol Sci. 2015 Mar;127(3):391-3. doi: 10.1016/j.jphs.2015.02.005. Epub 2015 Feb 9.

Authors

Affiliations

¹ Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
² Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
³ Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
⁴ Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan.
⁵ Department of Anesthesiology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan.
⁶ Department of Anesthesiology, Juntendo University, 3-1-3 Hongou, Bunkyo-ku, Tokyo 113-8431, Japan.
⁷ Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: ikeda-kz@igakuken.or.jp.

PMID: 25837939
DOI: 10.1016/j.jphs.2015.02.005

Abstract

An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene was suggested by our previous genome-wide association study. To verify this association, we analyzed the association between the rs1465040 SNP and analgesic requirements, including opioid requirements, after open abdominal surgery. The association between the rs1465040 SNP and postoperative analgesic requirements was confirmed in the open abdominal surgery group (P = 0.036), suggesting that the TRPC3 SNP may contribute to predicting postoperative analgesic requirements.

Keywords: Analgesics; Polymorphism; TRPC3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Analgesics / administration & dosage*
Analgesics, Opioid / administration & dosage
Female
Forecasting
Genome-Wide Association Study*
Humans
Male
Middle Aged
Orthognathic Surgical Procedures
Pain, Postoperative / drug therapy*
Pain, Postoperative / genetics*
Polymorphism, Single Nucleotide / genetics*
Postoperative Care*
TRPC Cation Channels / genetics*
Young Adult

Substances

Analgesics
Analgesics, Opioid
TRPC Cation Channels
TRPC3 cation channel