Understanding spatial and temporal variations in river water quality and quantitatively evaluating the trend of changes are important in order to study and efficiently manage water resources. In this study, an analysis of Water Pollution Index (WPI), Daniel Trend Test, Cluster Analysis and Discriminant Analysis are applied as an integrated approach to quantitatively explore the spatial and temporal variations and the latent sources of water pollution in the Shanchong River basin, Northwest Basin of Lake Fuxian, China. We group all field surveys into 2 clusters (dry season and rainy season). Moreover, 14 sampling sites have been grouped into 3 clusters for the rainy season (highly polluted, moderately polluted and less polluted sites) and 2 clusters for the dry season (highly polluted and less polluted sites) based on their similarities and the level of pollution during the two seasons. The results show that the main trend of pollution was aggravated during the transition from the dry to the rainy season. The Water Pollution Index of Total Nitrogen is the highest of all pollution parameters, whereas the Chemical Oxygen Demand (Chromium) is the lowest. Our results also show that the main sources of pollution are farming activities alongside the Shanchong River, soil erosion and fish culture at Shanchong River reservoir area and domestic sewage from scattered rural residential area. Our results suggest that strategies to prevent water pollutionat the Shanchong River basin need to focus on non-point pollution control by employing appropriate fertilizer formulas in farming, and take the measures of soil and water conservation at Shanchong reservoir area, and purifying sewage from scattered villages.