Epithelial cell division: keeping aneuploidy levels in check

Marta Clemente-Ruiz; Marco Milán

doi:10.1016/j.cub.2015.02.008

Epithelial cell division: keeping aneuploidy levels in check

Curr Biol. 2015 Mar 30;25(7):R275-7. doi: 10.1016/j.cub.2015.02.008.

Authors

Marta Clemente-Ruiz¹, Marco Milán²

Affiliations

¹ Institute for Research in Biomedicine, Parc Cientific de Barcelona, Baldiri Reixac, 10, 08028 Barcelona, Spain.
² Institute for Research in Biomedicine, Parc Cientific de Barcelona, Baldiri Reixac, 10, 08028 Barcelona, Spain; ICREA, Parc Cientific de Barcelona, Baldiri Reixac, 10-12, 08028 Barcelona, Spain. Electronic address: marco.milan@irbbarcelona.org.

PMID: 25829010
DOI: 10.1016/j.cub.2015.02.008

Abstract

Aneuploidy is deleterious at the cellular and organismal level and can promote tumorigenesis. Two new studies in Drosophila imaginal discs underscore the cellular and tissue-wide mechanisms that prevent the accumulation of aneuploid cells in symmetrically dividing epithelial tissues upon changes in centrosome number.

MeSH terms

Aneuploidy*
Animals
Cell Division / physiology*
Centrosome / physiology*
Drosophila
Epithelial Cells / cytology*