Condensation of tissue and stem cells for fat grafting

Shinichiro Kuno; Kotaro Yoshimura

doi:10.1016/j.cps.2014.12.006

Condensation of tissue and stem cells for fat grafting

Clin Plast Surg. 2015 Apr;42(2):191-7. doi: 10.1016/j.cps.2014.12.006. Epub 2015 Jan 31.

Authors

Shinichiro Kuno¹, Kotaro Yoshimura²

Affiliations

¹ Department of Plastic Surgery, School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan.
² Department of Plastic Surgery, School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan. Electronic address: kotaro-yoshimura@umin.ac.jp.

PMID: 25827563
DOI: 10.1016/j.cps.2014.12.006

Abstract

Aspirated fat contains unnecessary components such as water, oil, and blood cells. For better outcomes, tissue purification and condensation are useful, especially when injection volume to the recipient site is limited. Because aspirated fat is relatively poor in adipose-derived stem/stromal cells (ASCs), ASC condensation seems important for obtaining better regeneration and retention. Reducing tissue volume by removing some adipocytes or supplementation of stromal vascular fraction or ASCs can increase the ASC/adipocyte ratio in the graft. Clinical results of ASC supplementation remain controversial, but ASC condensation seems to lead to expanding applications of fat grafting into revitalization of stem cell-depleted tissue.

Keywords: Adipose-derived stem/stromal cell; Cell assisted lipotransfer; Fat grafting; Macrophages; Tissue regeneration; Vascular endothelial cells.

Publication types

Review

MeSH terms

Adipocytes / transplantation
Adipose Tissue / transplantation*
Humans
Lipectomy*
Stem Cell Transplantation / methods*
Stem Cells / cytology*