Adipose stem cells: biology, safety, regulation, and regenerative potential

Danielle M Minteer; Kacey G Marra; J Peter Rubin

doi:10.1016/j.cps.2014.12.007

Adipose stem cells: biology, safety, regulation, and regenerative potential

Clin Plast Surg. 2015 Apr;42(2):169-79. doi: 10.1016/j.cps.2014.12.007.

Authors

Danielle M Minteer¹, Kacey G Marra², J Peter Rubin³

Affiliations

¹ Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
² Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA; Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15213, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15213, USA.
³ Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA; Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15213, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15213, USA. Electronic address: rubipj@upmc.edu.

PMID: 25827561
DOI: 10.1016/j.cps.2014.12.007

Abstract

This article discusses adipose-derived stem cell (ASC) biology, describes the current knowledge in the literature for the safety and regulation of ASCs, and provides a brief overview of the regenerative potential of ASCs. It is not an exhaustive listing of all available clinical studies or every study applying ASCs in tissue engineering and regenerative medicine, but is an objective commentary of these topics.

Keywords: Adipose; Adipose-derived stem cells; Clinical translation; Mesenchymal stem cells; Regenerative medicine; Stem cell safety; Stromal vascular fraction; Tissue engineering.

Publication types

Review

MeSH terms

Adipocytes / cytology
Adipocytes / transplantation
Adipose Tissue / cytology*
Adipose Tissue / transplantation
Humans
Regenerative Medicine / methods*
Stem Cell Transplantation*
Stem Cells / cytology*
Tissue Engineering / methods*