Mutual interaction between BCL6 and microRNAs in T cell differentiation

RNA Biol. 2015;12(1):21-5. doi: 10.1080/15476286.2015.1017232.

Abstract

The transcription factor B-cell CLL/lymphoma 6 (BCL6) and the regulatory factor microRNAs (miRNAs) are of great importance in the differentiation of T cell subsets. An increasing body of evidence has demonstrated that BCL6 and miRNAs can target one another and mutually adjust their expression in T cell subsets, such as T helper (Th)-2, Th17, CD8+ regulatory T (CD8+Treg) and T follicular helper (Tfh) cells. Here, we discuss the most recent advances and emerging concepts in how BCL6 and miRNAs regulate one another, and the effects of such mutual regulations on T cell subset differentiation.

Keywords: BCL6; T lymphocyte; differentiation; interaction; miRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation*
  • DNA-Binding Proteins / metabolism*
  • Humans
  • MicroRNAs / metabolism*
  • Proto-Oncogene Proteins c-bcl-6
  • T-Lymphocyte Subsets / metabolism*
  • T-Lymphocytes / metabolism*

Substances

  • BCL6 protein, human
  • DNA-Binding Proteins
  • MicroRNAs
  • Proto-Oncogene Proteins c-bcl-6