How gene expression in fast-proliferating cells keeps pace

Rui G Martinho; Leonardo G Guilgur; Pedro Prudêncio

doi:10.1002/bies.201400195

How gene expression in fast-proliferating cells keeps pace

Bioessays. 2015 May;37(5):514-24. doi: 10.1002/bies.201400195. Epub 2015 Mar 30.

Authors

Rui G Martinho¹, Leonardo G Guilgur, Pedro Prudêncio

Affiliation

¹ Departamento de Ciências Biomédicas e Medicina, Regenerative Medicine Program, Universidade do Algarve, Campus de Gambelas, Faro, Portugal; Center for Biomedical Research, Universidade do Algarve, Campus de Gambelas, Faro, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal.

PMID: 25823409
DOI: 10.1002/bies.201400195

Abstract

The development of living organisms requires a precise coordination of all basic cellular processes, in space and time. Early embryogenesis of most species with externally deposited eggs starts with a series of extremely fast cleavage cycles. These divisions have a strong influence on gene expression as mitosis represses transcription and pre-mRNA processing. In this review, we will describe the distinct adaptations for efficient gene expression and discuss the emerging role of the multifunctional NineTeen Complex (NTC) in gene expression and genomic stability during fast proliferation.

Keywords: MBT; MZT; NTC/Prp19; drosophila; intronless genes; splicing; transcription.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Proliferation / genetics
Cell Proliferation / physiology
Gene Expression / physiology*
Humans
RNA Precursors / genetics*
RNA Splicing / genetics
Spliceosomes / genetics*

Substances

RNA Precursors