Hybrid encapsulation structures based on β-carotene-loaded nanoliposomes within electrospun fibers

Rafael Henrique de Freitas Zômpero; Amparo López-Rubio; Samantha Cristina de Pinho; José María Lagaron; Lucimara Gaziola de la Torre

doi:10.1016/j.colsurfb.2015.03.015

Hybrid encapsulation structures based on β-carotene-loaded nanoliposomes within electrospun fibers

Colloids Surf B Biointerfaces. 2015 Oct 1:134:475-82. doi: 10.1016/j.colsurfb.2015.03.015. Epub 2015 Mar 14.

Authors

Rafael Henrique de Freitas Zômpero¹, Amparo López-Rubio², Samantha Cristina de Pinho³, José María Lagaron⁴, Lucimara Gaziola de la Torre⁵

Affiliations

¹ School of Chemical Engineering, University of Campinas, UNICAMP P.O. Box 6066, 13083-970, Campinas-SP, Brazil.
² Novel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology, IATA, 46980 Paterna, Valencia, Spain.
³ Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
⁴ School of Chemical Engineering, University of Campinas, UNICAMP P.O. Box 6066, 13083-970, Campinas-SP, Brazil; Novel Materials and Nanotechnology Group, Institute of Agrochemistry and Food Technology, IATA, 46980 Paterna, Valencia, Spain; Department of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo (USP), Pirassununga, SP, Brazil.
⁵ School of Chemical Engineering, University of Campinas, UNICAMP P.O. Box 6066, 13083-970, Campinas-SP, Brazil. Electronic address: latorre@feq.unicamp.br.

PMID: 25819464
DOI: 10.1016/j.colsurfb.2015.03.015

Abstract

Hybrid encapsulation structures based on β-carotene-loaded nanoliposomes incorporated within the polymeric ultrathin fibers produced through electrospinning were developed to improve the photostability of the antioxidant. These novel materials were intended to incorporate β-carotene into water-based food formulations, overcoming the existing limitations associated with its hydrophobic character. Initially, both empty and antioxidant-loaded nanoliposomes were developed and incorporated into polyvinyl alcohol (PVOH) and polyethylene oxide (PEO) solutions. The changes in the solution properties were evaluated to determine their effects on the electrospinning processing. The mixed polymer solutions were subsequently electrospun to produce hybrid nanoliposome-loaded ultrathin fibers. FTIR analysis confirmed the presence of phospholipid molecules inside the electrospun fibers. These ultrathin fibers were evaluated regarding their morphology, diameter, internal β-carotene distribution and stability against UV irradiation. Liposomal release studies from the electrospun fibers were also undertaken, confirming the presence of the liposomal structures after dissolving the electrospun fibers in water.

Keywords: Nanofiber; Nanoliposomes; Polyethylene oxide; Polyvinyl alcohol.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Liposomes*
Microscopy, Electron, Scanning
Nanostructures
Spectroscopy, Fourier Transform Infrared
beta Carotene / chemistry*

Substances

Liposomes
beta Carotene