MARK-AGE biomarkers of ageing

Alexander Bürkle; María Moreno-Villanueva; Jürgen Bernhard; María Blasco; Gerben Zondag; Jan H J Hoeijmakers; Olivier Toussaint; Beatrix Grubeck-Loebenstein; Eugenio Mocchegiani; Sebastiano Collino; Efstathios S Gonos; Ewa Sikora; Daniela Gradinaru; Martijn Dollé; Michel Salmon; Peter Kristensen; Helen R Griffiths; Claude Libert; Tilman Grune; Nicolle Breusing; Andreas Simm; Claudio Franceschi; Miriam Capri; Duncan Talbot; Paola Caiafa; Bertrand Friguet; P Eline Slagboom; Antti Hervonen; Mikko Hurme; Richard Aspinall

doi:10.1016/j.mad.2015.03.006

MARK-AGE biomarkers of ageing

Mech Ageing Dev. 2015 Nov:151:2-12. doi: 10.1016/j.mad.2015.03.006. Epub 2015 Mar 24.

Authors

Alexander Bürkle¹, María Moreno-Villanueva², Jürgen Bernhard³, María Blasco⁴, Gerben Zondag⁵, Jan H J Hoeijmakers⁶, Olivier Toussaint⁷, Beatrix Grubeck-Loebenstein⁸, Eugenio Mocchegiani⁹, Sebastiano Collino¹⁰, Efstathios S Gonos¹¹, Ewa Sikora¹², Daniela Gradinaru¹³, Martijn Dollé¹⁴, Michel Salmon¹⁵, Peter Kristensen¹⁶, Helen R Griffiths¹⁷, Claude Libert¹⁸, Tilman Grune¹⁹, Nicolle Breusing²⁰, Andreas Simm²¹, Claudio Franceschi²², Miriam Capri²², Duncan Talbot²³, Paola Caiafa²⁴, Bertrand Friguet²⁵, P Eline Slagboom²⁶, Antti Hervonen²⁷, Mikko Hurme²⁷, Richard Aspinall²⁸

Affiliations

¹ Molecular Toxicology Group, Department of Biology, Box 628, University of Konstanz, 78457 Konstanz, Germany. Electronic address: alexander.buerkle@uni-konstanz.de.
² Molecular Toxicology Group, Department of Biology, Box 628, University of Konstanz, 78457 Konstanz, Germany.
³ BioTeSys GmbH, 73728 Esslingen, Germany.
⁴ Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro, 28029 Madrid, Spain.
⁵ DNage BV(1), Leiden, The Netherlands.
⁶ Department of Genetics, Erasmus University Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
⁷ University of Namur, Research Unit on Cellular Biology, Rue de Bruxelles, 61, Namur B-5000, Belgium.
⁸ Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, 6020 Innsbruck, Austria.
⁹ Translational Research Center of Nutrition and Ageing, IRCCS-INRCA, Via Birarelli 8, 60121 Ancona, Italy.
¹⁰ Nestlé Institute of Health Sciences SA, Molecular Biomarkers, EPFL Innovation Park, 1015 Lausanne, Switzerland.
¹¹ National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
¹² Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, 02-093 Warsaw, Poland.
¹³ Ana Aslan - National Institute of Gerontology and Geriatrics, Bucharest, Romania.
¹⁴ National Institute for Public Health and the Environment (RIVM), Centre for Prevention and Health Services Research, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
¹⁵ Straticell, Science Park Crealys, Rue Jean Sonet 10, 5032 Les Isnes, Belgium.
¹⁶ Department of Engineering - BCE Protein Engineering, Gustav Wiedsvej 10, 8000 Aarhus, Denmark.
¹⁷ Life and Health Sciences, Aston Research Centre for Healthy Ageing, Aston University, Birmingham, UK.
¹⁸ Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
¹⁹ Institute of Nutritional Medicine, University of Hohenheim, 70593 Stuttgart, Germany; Department of Nutritional Toxicology, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
²⁰ Institute of Nutritional Medicine, University of Hohenheim, 70593 Stuttgart, Germany.
²¹ Department of Cardiothoracic Surgery, University Hospital Halle, Ernst-Grube Str. 40, 06120 Halle (Saale), Germany.
²² CIG-Interdepartmental Center "L.Galvani", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
²³ Unilever Corporate Research, Sharnbrook, UK.
²⁴ Department of Cellular Biotechnologies and Hematology, Faculty of Pharmacy and Medicine, "Sapienza" University Rome, V.le Regina Elena 324, 00161 Rome, Italy.
²⁵ Sorbonne Universités, UPMC Univ Paris 06, UMR UPMC CNRS 8256, Biological adaptation and ageing - IBPS, INSERM U1164, F-75005 Paris, France.
²⁶ Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
²⁷ Medical School, University of Tampere, 33014 Tampere, Finland.
²⁸ Regenerative Medicine Group, Cranfield Health, Cranfield, UK.

PMID: 25818235
DOI: 10.1016/j.mad.2015.03.006

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Keywords: Ageing biomarkers; Human studies; MARK-AGE.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / metabolism*
Biomarkers / metabolism*
European Union
Female
Humans
Male

Substances

Biomarkers