Comparative bone tissue integration of nanostructured and microroughened dental implants

Nanomedicine (Lond). 2015;10(5):741-51. doi: 10.2217/nnm.14.223.

Abstract

Aim: The aim was to compare osteointegration of nanostructured implants to a microsurface widely used for titanium dental implants.

Materials & methods: Commercial titanium dental implants with smooth or microroughened surfaces were nanostructured. Implants were inserted into the femoral condyles of rabbits. After 2 and 4 weeks, histomorphometry calculation was performed.

Results: Nanotubes measuring 60 nm in diameter were observed on both S-NANO (roughness: 0.05 μm) and R-NANO (roughness: 0.40 μm) surfaces. The MICRO surface exhibited typical random cavities (roughness: 2.09 μm). At 4 weeks, bone-to-implant contact values were significantly higher for the R-NANO than for the MICRO surface while no differences were observed at 2 weeks.

Conclusion: Overall, this study shows that the nanostructured surfaces improved osteointegration similar or higher than the MICRO.

Keywords: bone-to-implant contact; dental implant; nanostructure; osseointegration; titanium.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dental Implants*
  • Female
  • Femur / surgery
  • Metal Nanoparticles
  • Microscopy, Electron, Scanning
  • Nanomedicine
  • Nanostructures*
  • Nanotubes
  • Osseointegration*
  • Prosthesis Design
  • Rabbits
  • Surface Properties
  • Titanium

Substances

  • Dental Implants
  • Titanium