Abstract
Nanoparticles have attracted a great deal of attention as carriers for drug delivery to cancer cells. However, reports on their potential cytotoxicity raise questions of their safety and this matter needs attentive consideration. In this paper, for the first time, the cytotoxic effects of two carbon based nanoparticles, diamond and graphite, on glioblastoma and hepatoma cells were compared. First, we confirmed previous results that diamond nanoparticles are practically nontoxic. Second, graphite nanoparticles exhibited a negative impact on glioblastoma, but not on hepatoma cells. The studied carbon nanoparticles could be a potentially useful tool for therapeutics delivery to the brain tissue with minimal side effects on the hepatocytes. Furthermore, we showed the influence of the nanoparticles on the stable, fluorescently labeled tumor cell lines and concluded that the labeled cells are suitable for drug cytotoxicity tests.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbon / administration & dosage
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Carbon / adverse effects
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Carcinoma, Hepatocellular / drug therapy*
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Carcinoma, Hepatocellular / pathology
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Cell Survival / drug effects
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Diamond / administration & dosage
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Diamond / adverse effects
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Diamond / chemistry
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Drug Delivery Systems / adverse effects
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Glioblastoma / drug therapy*
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Glioblastoma / pathology
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Graphite / administration & dosage
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Graphite / adverse effects
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Graphite / chemistry
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Hepatocytes / drug effects
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Humans
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Liver Neoplasms / drug therapy*
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Nanoparticles / administration & dosage*
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Nanoparticles / adverse effects
Grants and funding
Funding provided by National Science Centre Poland NCN 2011/03/N/NZ9/04290,
http://www.ncn.gov.pl MW; European Regional Development Found within the POIG Programme: MNS-DIAG “Micro- and Nano- Systems for Chemistry and Biomedical Diagnostics” (POIG.01.03.01-00-014/08-02),
www.projekty.poig.gov.pl DGP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.