Abstract
Five flavonostilbenes (alopecurones H, I, J, K and L) and five known ones were isolated from roots of Sophora alopecuroides, in addition to ten other phenolic compounds. A non-enzymatic interconversion of the lavandulyl-substituted flavonostilbenes was observed among alopecurones A, H, I, and K through a Wessely-Moser rearrangement reaction; this was proven by 1D and 2D NMR, HPLC-CD-PDA and HRMS analyses. Bioassay results suggested that flavonostilbenes exhibit significant antibacterial and anti-biofilm formation activities against Staphylococcus epidermidis with MIC values ranging from 3.1 to 12.5μg/mL.
Keywords:
Antibacterial activity; Bitterbean Sophora alopecuroides; Flavonostilbenes; Leguminosae.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Chromatography, High Pressure Liquid
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Sophora / chemistry
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Staphylococcus epidermidis / drug effects
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Stilbenes / chemistry
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Drugs, Chinese Herbal
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Flavonoids
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Stilbenes
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alopecurone H