NPM1 mutations may reveal acute myeloid leukemia in cases otherwise morphologically diagnosed as myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms

Leuk Lymphoma. 2015;56(11):3222-6. doi: 10.3109/10428194.2015.1026900. Epub 2015 May 12.

Authors

Fabio Forghieri¹, Ambra Paolini¹, Monica Morselli¹, Sara Bigliardi¹, Goretta Bonacorsi¹, Giovanna Leonardi¹, Valeria Coluccio¹, Monica Maccaferri¹, Valeria Fantuzzi¹, Laura Faglioni¹, Elisabetta Colaci¹, Francesco Soci¹, Vincenzo Nasillo¹, Andrea Messerotti¹, Laura Arletti¹, Valeria Pioli¹, Patrizia Zucchini¹, Chiara Quadrelli¹, Giorgia Corradini¹, Francesca Giacobbi¹, Daniela Vallerini¹, Giovanni Riva¹, Patrizia Barozzi¹, Ivana Lagreca¹, Roberto Marasca¹, Franco Narni¹, Cristina Mecucci², Emanuela Ottaviani³, Giovanni Martinelli³, Brunangelo Falini², Mario Luppi¹, Leonardo Potenza¹

Affiliations

¹ a Department of Medical and Surgical Sciences , Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico , Modena , Italy.
² b Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine , University of Perugia . Perugia , Italy.
³ c Institute of Hematology "L. e A. Seràgnoli", Department of Experimental , Diagnostic and Specialty Medicine, University of Bologna , Bologna , Italy.

PMID: 25813079
DOI: 10.3109/10428194.2015.1026900

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Biopsy
Bone Marrow / pathology
Cell Transformation, Neoplastic / genetics
DNA Mutational Analysis
Female
Humans
Leukemia, Myeloid, Acute / diagnosis
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Mutation*
Myelodysplastic Syndromes / diagnosis
Myelodysplastic Syndromes / genetics*
Myeloproliferative Disorders / diagnosis
Myeloproliferative Disorders / genetics*
Nuclear Proteins / genetics*
Nucleophosmin

Substances

NPM1 protein, human
Nuclear Proteins
Nucleophosmin