Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27

Yuqing Duan; Yunlong Jia; Tingting Wang; Yu Wang; Xiaonan Han; Lihua Liu

doi:10.1016/j.intimp.2015.03.016

Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27

Int Immunopharmacol. 2015 May;26(1):139-46. doi: 10.1016/j.intimp.2015.03.016. Epub 2015 Mar 24.

Authors

Yuqing Duan¹, Yunlong Jia¹, Tingting Wang¹, Yu Wang¹, Xiaonan Han¹, Lihua Liu²

Affiliations

¹ Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China.
² Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China. Electronic address: cdlihualiu@aliyun.com.

PMID: 25812768
DOI: 10.1016/j.intimp.2015.03.016

Abstract

Interleukin (IL)-27 is an important pleiotropic immunological regulator for having dual effects on the immune responses. Several distinct findings have been highlighted that in certain conditions, neutralizing IL-27 or its subunit IL-27p28 might be a useful strategy to limit inflammation. Recently more insights have revealed that IL-27 could also exert potent inhibitory functions in some other immune circumstances including virus infection and tumor immunity. In this review, we describe IL-27 receptor subunits and the mechanisms of individual IL-27, and summarize the advances of their preclinical application trials. In addition, the potential role of IL-27 as a clinical therapeutic target will also be discussed.

Keywords: Anti-tumor immunity; IL-27p28; Inflammation; Interleukin-27; Virus infection.

Publication types

Review

MeSH terms

Autoimmune Diseases / immunology*
Autoimmune Diseases / therapy
Humans
Interleukin-27 / immunology*
Interleukin-27 / metabolism
Interleukin-27 / therapeutic use
Molecular Targeted Therapy*
Neoplasms / immunology*
Neoplasms / therapy
Virus Diseases / immunology*
Virus Diseases / therapy

Substances

Interleukin-27