New organochalcogen multitarget drug: synthesis and antioxidant and antitumoral activities of chalcogenozidovudine derivatives

J Med Chem. 2015 Apr 23;58(8):3329-39. doi: 10.1021/jm5015296. Epub 2015 Apr 8.

Abstract

In this article we present the synthesis, characterization, and in vitro biological and biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of TBARS in brain membranes and thiol peroxidase-like activity) as well as antitumoral agents in bladder carcinoma 5637. A prominent response was obtained for the selected chalcogenonucleosides, showing effective antioxidant and antitumoral activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Apoptosis / drug effects
  • Cell Line, Tumor
  • Chalcogens / chemical synthesis
  • Chalcogens / chemistry*
  • Chalcogens / pharmacology
  • Humans
  • Male
  • Rats, Wistar
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Urinary Bladder / drug effects
  • Urinary Bladder / metabolism
  • Urinary Bladder / pathology
  • Urinary Bladder Neoplasms / drug therapy*
  • Urinary Bladder Neoplasms / metabolism
  • Urinary Bladder Neoplasms / pathology
  • Zidovudine / chemical synthesis
  • Zidovudine / chemistry*
  • Zidovudine / pharmacology

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Chalcogens
  • Thiobarbituric Acid Reactive Substances
  • Zidovudine