Abstract
Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.
Keywords:
CDK16; GALNT7; Nasopharyngeal carcinoma; Tumor suppressor; miR-494.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / genetics
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Carcinogenesis / genetics
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Carcinoma
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Cell Line, Tumor
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Cell Proliferation / genetics
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Cyclin-Dependent Kinases / genetics*
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Gene Expression Regulation, Neoplastic
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Humans
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MicroRNAs / biosynthesis*
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MicroRNAs / genetics
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N-Acetylgalactosaminyltransferases / genetics*
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Nasopharyngeal Carcinoma
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Nasopharyngeal Neoplasms / genetics*
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Nasopharyngeal Neoplasms / pathology
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Neoplasm Invasiveness / genetics
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
Substances
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MIRN494 microRNA, human
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MicroRNAs
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RNA, Messenger
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N-Acetylgalactosaminyltransferases
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UDP-N-acetylgalactosamine--polypeptide N-acetylgalactosaminyltransferase 7
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Cyclin-Dependent Kinases
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PCTAIRE-1 protein kinase