Plasma H2S predicts coronary artery lesions in children with Kawasaki disease

Pediatr Int. 2015 Oct;57(5):840-4. doi: 10.1111/ped.12631. Epub 2015 May 29.

Abstract

Background: The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD).

Methods: A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2 S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out.

Results: Plasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children.

Conclusion: Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.

Keywords: Kawasaki disease; hydrogen sulfide; inflammation; vasculitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aftercare
  • Biomarkers / blood
  • Case-Control Studies
  • Child, Preschool
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnosis*
  • Coronary Vessels / diagnostic imaging*
  • Echocardiography, Doppler, Color
  • Female
  • Humans
  • Hydrogen Sulfide / blood*
  • Infant
  • Male
  • Mucocutaneous Lymph Node Syndrome / blood*
  • Mucocutaneous Lymph Node Syndrome / complications
  • Mucocutaneous Lymph Node Syndrome / diagnosis
  • Predictive Value of Tests
  • Prospective Studies
  • ROC Curve

Substances

  • Biomarkers
  • Hydrogen Sulfide