Interventional pulmonology approaches in the diagnosis and treatment of early stage non small cell lung cancer

Transl Lung Cancer Res. 2013 Oct;2(5):316-31. doi: 10.3978/j.issn.2218-6751.2013.10.11.

Abstract

Lung cancer management is complex and requires a multi-disciplinary approach to provide comprehensive care. Interventional pulmonology (IP) is an evolving field that utilizes minimally invasive modalities for the initial diagnosis and staging of suspected lung cancers. Endobronchial ultrasound guided sampling of mediastinal lymph nodes for staging and detection of driver mutations is instrumental for prognosis and treatment of early and later stage lung cancers. Advances in navigational bronchoscopy allow for histological sampling of suspicious peripheral lesions with minimal complication rates, as well as assisting with fiducial marker placements for stereotactic radiation therapy. Furthermore, IP can also offer palliation for inoperable cancers and those with late stage diseases. As the trend towards early lung cancer detection with low dose computed tomography is developing, it is paramount for the pulmonary physician with expertise in lung nodule management, minimally invasive sampling and staging to integrate into the paradigm of multi-specialty care.

Keywords: Bronchoscopy; TNM staging; electromagnetic navigational bronchoscopy (ENB™); gene expression profiling; interdisciplinary communication; radial probe-EBUS (RP-EBUS); virtual bronchoscopic navigation (VBN).

Publication types

  • Review