Abstract
We report a novel electrochemical strategy to probe the microenvironment of live cells in real time in terms of its extracellular pH. This approach allowed highly sensitive detection of cancer cells down to five cells. Utility of the sensor for evaluating the efficacy of glycolysis inhibiting anti-cancer drugs is also demonstrated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Separation
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Cell Survival
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Drug Screening Assays, Antitumor
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Electrochemistry / methods*
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Extracellular Space / chemistry*
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Extracellular Space / drug effects*
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Humans
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Hydrogen-Ion Concentration
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Time Factors
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Tumor Microenvironment / drug effects