Mycobacterium tuberculosis-specific CD4 T cells are the principal source of IFN-γ in QuantiFERON assays in healthy persons

Tuberculosis (Edinb). 2015 May;95(3):350-1. doi: 10.1016/j.tube.2015.03.002. Epub 2015 Mar 10.

Authors

Adam Penn-Nicholson¹, Elisa Nemes², Willem A Hanekom², Mark Hatherill², Thomas J Scriba²

Affiliations

¹ South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. Electronic address: adam.penn-nicholson@uct.ac.za.
² South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.

PMID: 25802032
DOI: 10.1016/j.tube.2015.03.002

No abstract available

MeSH terms

Adult
Antigens, Bacterial / immunology
Bacterial Proteins / immunology
Biomarkers / metabolism
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / metabolism
CD4-Positive T-Lymphocytes / microbiology
Cross-Sectional Studies
Female
HIV Infections / diagnosis
HIV Infections / immunology
Healthy Volunteers
Humans
Interferon-gamma / immunology*
Interferon-gamma / metabolism
Interferon-gamma Release Tests*
Male
Middle Aged
Mycobacterium tuberculosis / immunology*
Predictive Value of Tests
Reproducibility of Results
South Africa
Young Adult

Substances

Antigens, Bacterial
Bacterial Proteins
Biomarkers
CFP-10 protein, Mycobacterium tuberculosis
ESAT-6 protein, Mycobacterium tuberculosis
IFNG protein, human
Interferon-gamma