MICA∗078: A novel allele identified in a Moroccan individual affected by celiac disease

Hum Immunol. 2015 Jun;76(6):438-41. doi: 10.1016/j.humimm.2015.03.013. Epub 2015 Mar 20.

Abstract

A novel MICA allele, MICA(∗)078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA(∗)078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G → A), resulting in one amino acid change at codon 142 (V → I) of MICA gene (compared to MICA(∗)002:01), located in the α2-domain, in which V142 is the common residue.

Keywords: Allele; Celiac; MICA; SBT.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • Celiac Disease / genetics*
  • Celiac Disease / immunology
  • Celiac Disease / pathology
  • Codon
  • Female
  • Founder Effect*
  • Gene Expression
  • Histocompatibility Antigens Class I / genetics*
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Testing
  • Humans
  • Middle Aged
  • Models, Molecular
  • Molecular Sequence Data
  • Morocco
  • Polymorphism, Single Nucleotide*
  • Protein Structure, Tertiary
  • Sequence Alignment

Substances

  • Codon
  • Histocompatibility Antigens Class I
  • MHC class I-related chain A

Associated data

  • GENBANK/KF530029