Abstract
A novel MICA allele, MICA(∗)078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA(∗)078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G → A), resulting in one amino acid change at codon 142 (V → I) of MICA gene (compared to MICA(∗)002:01), located in the α2-domain, in which V142 is the common residue.
Keywords:
Allele; Celiac; MICA; SBT.
Copyright © 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Amino Acid Sequence
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Base Sequence
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Celiac Disease / genetics*
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Celiac Disease / immunology
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Celiac Disease / pathology
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Codon
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Female
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Founder Effect*
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Gene Expression
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class I / immunology
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Histocompatibility Testing
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Humans
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Middle Aged
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Models, Molecular
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Molecular Sequence Data
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Morocco
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Polymorphism, Single Nucleotide*
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Protein Structure, Tertiary
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Sequence Alignment
Substances
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Codon
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Histocompatibility Antigens Class I
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MHC class I-related chain A