HLA-A, -B, -C, and -DRB1 genotyping of 1000 Northern Irish individuals from Belfast, Northern Ireland in the United Kingdom

Williams Fionnuala; Middleton Derek

doi:10.1016/j.humimm.2015.03.015

HLA-A, -B, -C, and -DRB1 genotyping of 1000 Northern Irish individuals from Belfast, Northern Ireland in the United Kingdom

Hum Immunol. 2015 Jun;76(6):395-6. doi: 10.1016/j.humimm.2015.03.015. Epub 2015 Mar 19.

Authors

Williams Fionnuala¹, Middleton Derek²

Affiliations

¹ Northern Ireland Histocompatibility and Immunogenetics Laboratory, Belfast City Hospital, Belfast, Northern Ireland, UK.
² Transplant Immunology, Royal Liverpool Hospital, Liverpool, UK. Electronic address: Derek.Middleton@rlbuht.nhs.uk.

PMID: 25797202
DOI: 10.1016/j.humimm.2015.03.015

Abstract

One thousand individuals from Belfast, Northern Ireland were genotyped at the HLA-A, -B, -C and -DRB1 loci using sequence-specific oligonucleotide probe methods. HLA-A locus genotypes display a minor Hardy-Weinberg (HW) deviation (p=0.0375); HLA-B, -C and -DRB1 genotypes are consistent with expected HW proportions. These genotype data are available in the Allele Frequencies Net Database under identifier AFND 1243.

MeSH terms

Alleles
Gene Frequency
Genetic Loci
Genetics, Population
Genome, Human
Genotyping Techniques
HLA-A Antigens / classification
HLA-A Antigens / genetics*
HLA-A Antigens / immunology
HLA-B Antigens / classification
HLA-B Antigens / genetics*
HLA-B Antigens / immunology
HLA-C Antigens / classification
HLA-C Antigens / genetics*
HLA-C Antigens / immunology
HLA-DRB1 Chains / classification
HLA-DRB1 Chains / genetics*
HLA-DRB1 Chains / immunology
Humans
Northern Ireland

Substances

HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
HLA-DRB1 Chains