A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro

Pak J Pharm Sci. 2015 Mar;28(2 Suppl):745-53.

Abstract

A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albizzia* / chemistry
  • Animals
  • Dose-Response Relationship, Drug
  • Flowers
  • Guinea Pigs
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plants, Medicinal
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / isolation & purification
  • Platelet Aggregation Inhibitors / pharmacology*
  • beta-Lactams / chemistry
  • beta-Lactams / isolation & purification
  • beta-Lactams / pharmacology*

Substances

  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • albactam
  • beta-Lactams