Abstract
A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Albizzia* / chemistry
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Animals
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Dose-Response Relationship, Drug
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Flowers
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Guinea Pigs
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Phytotherapy
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plants, Medicinal
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / isolation & purification
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Platelet Aggregation Inhibitors / pharmacology*
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beta-Lactams / chemistry
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beta-Lactams / isolation & purification
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beta-Lactams / pharmacology*
Substances
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Plant Extracts
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Platelet Aggregation Inhibitors
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albactam
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beta-Lactams