Molecular toggle switch of histone demethylase LSD1

Jaehoon Shin; Guo-Li Ming; Hongjun Song

doi:10.1016/j.molcel.2015.03.007

Molecular toggle switch of histone demethylase LSD1

Mol Cell. 2015 Mar 19;57(6):949-950. doi: 10.1016/j.molcel.2015.03.007.

Authors

Jaehoon Shin¹, Guo-Li Ming², Hongjun Song³

Affiliations

¹ Graduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
² Graduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
³ Graduate Program in Cellular and Molecular Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: shongju1@jhmi.edu.

Abstract

In this issue of Molecular Cell, Laurent et al. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.

Publication types

Comment

MeSH terms

Histone Demethylases / metabolism*
Humans
Membrane Proteins / metabolism*
Microfilament Proteins / metabolism*
Neurons / metabolism*

Substances

Membrane Proteins
Microfilament Proteins
SVIL protein, human
Histone Demethylases
KDM1A protein, human

Abstract

Publication types

MeSH terms

Substances

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