Predictors of Abnormal Neuroimaging of the Brain in Children With Epilepsy Aged 1 Month to 2 Years: Useful Clues in a Resource-Limited Setting

J Child Neurol. 2015 Oct;30(11):1532-6. doi: 10.1177/0883073815574199. Epub 2015 Mar 19.

Abstract

Neuroimaging should be performed on infants with seizure. However, there are economic limitations in performing neuroimaging in a resource-limited setting. The younger the age, the higher the risk of having abnormal neuroimaging. The aim was to determine frequency and predictors of abnormal neuroimaging in children with epilepsy aged 1 month to 2 years. History, physical examination, electroencephalogram (EEG), and neuroimaging were reviewed. Thirty-seven of 49 (76%) had neuroimaging studies; 19 computed tomography (CT), 14 magnetic resonance imaging (MRI), and 4 had both. Abnormal neuroimaging was found in 19 (51%). Predictors of abnormal neuroimages are developmental delay, abnormal head circumference, and abnormal neurologic examination. Eight children (21%) had lesions on neuroimaging studies that altered or influenced management. Of 8 patients with normal examination and EEG, 1 had a brain tumor and another had arteriovenous malformation. Neuroimaging should be considered as an essential aid in the evaluation of infants with epilepsy, even in a resource-limited setting.

Keywords: electroencephalogram; epilepsy; infant; neuroimaging; seizure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / pathology*
  • Brain Neoplasms / complications
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / pathology
  • Brain Neoplasms / physiopathology
  • Child, Preschool
  • Developmental Disabilities / complications
  • Developmental Disabilities / diagnosis
  • Developmental Disabilities / pathology
  • Developmental Disabilities / physiopathology
  • Electroencephalography
  • Epilepsy / complications
  • Epilepsy / diagnosis*
  • Epilepsy / pathology*
  • Epilepsy / physiopathology
  • Female
  • Head / pathology
  • Humans
  • Infant
  • Intracranial Arteriovenous Malformations / complications
  • Intracranial Arteriovenous Malformations / diagnosis
  • Intracranial Arteriovenous Malformations / pathology
  • Intracranial Arteriovenous Malformations / physiopathology
  • Magnetic Resonance Imaging
  • Male
  • Neurologic Examination
  • Organ Size
  • Physical Examination
  • Prognosis
  • Retrospective Studies
  • Tomography, X-Ray Computed