Overexpression of JMJD3 may contribute to demethylation of H3K27me3 in CD4+ T cells from patients with systemic sclerosis

Clin Immunol. 2015 Dec;161(2):396-9. doi: 10.1016/j.clim.2015.03.006. Epub 2015 Mar 17.

Authors

Qing Wang¹, Yangfan Xiao¹, Yaqian Shi¹, Yangyang Luo¹, YaPing Li¹, Ming Zhao², Qianjin Lu², Rong Xiao³

Affiliations

¹ Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China.
³ Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: xiaorong65@aliyun.com.

PMID: 25791244
DOI: 10.1016/j.clim.2015.03.006

No abstract available

Keywords: CD4+ T cell; H3K27me3; JMJD3; Systemic sclerosis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blotting, Western
CD4-Positive T-Lymphocytes / metabolism*
Female
Gene Expression*
Histones / metabolism*
Humans
Jumonji Domain-Containing Histone Demethylases / genetics*
Jumonji Domain-Containing Histone Demethylases / metabolism
Lysine / metabolism
Male
Methylation
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction
Scleroderma, Systemic / genetics*
Scleroderma, Systemic / metabolism

Substances

Histones
Jumonji Domain-Containing Histone Demethylases
KDM6B protein, human
Lysine