Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Pediatr Blood Cancer. 2015 Jul;62(7):1294-6. doi: 10.1002/pbc.25482. Epub 2015 Mar 19.

Abstract

Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B-cell non-Hodgkin lymphoma (B-NHL). We performed a review of 79 abnormal karyotypes in childhood B-NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event-free survival in Burkitt or Burkitt-like lymphoma. The adverse prognosis of MYC/8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B-NHL.

Keywords: B-NHL03; JPLSG; childhood; cytogenetic abnormality; non-Hodgkin lymphoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Chromosome Aberrations*
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphoma, B-Cell / genetics*
  • Lymphoma, B-Cell / mortality*
  • Lymphoma, B-Cell / therapy
  • Male
  • Neoplasm Staging
  • Prognosis
  • Proto-Oncogene Proteins c-myc / genetics*
  • Survival Rate

Substances

  • MYC protein, human
  • Proto-Oncogene Proteins c-myc