Small RNA: from development to regeneration

Ge Tao; Jun Wang; James F Martin

doi:10.1126/scitranslmed.aaa7538

Small RNA: from development to regeneration

Sci Transl Med. 2015 Mar 18;7(279):279fs12. doi: 10.1126/scitranslmed.aaa7538. Epub 2015 Mar 18.

Authors

Ge Tao¹, Jun Wang¹, James F Martin²

Affiliations

¹ Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Cardiovascular Research institute, Baylor College of Medicine, Houston, TX 77030, USA.
² Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Cardiovascular Research institute, Baylor College of Medicine, Houston, TX 77030, USA. Texas Heart Institute, Houston, TX 77030, USA. Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA. jfmartin@bcm.edu.

PMID: 25787761
DOI: 10.1126/scitranslmed.aaa7538

Abstract

A microRNA cluster that targets the Hippo pathway can reintroduce terminally differentiated cardiomyocytes into the cell cycle, promoting heart regeneration (Tian et al., this issue).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Male
MicroRNAs / metabolism*
Myocytes, Cardiac / cytology*
Protein Serine-Threonine Kinases / metabolism*

Substances

MicroRNAs
Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding