Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy

Kaimei Ke; Lisen Lin; Hong Liang; Xian Chen; Chao Han; Juan Li; Huang-Hao Yang

doi:10.1039/c5cc01129a

Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy

Chem Commun (Camb). 2015 Apr 21;51(31):6800-3. doi: 10.1039/c5cc01129a.

Authors

Kaimei Ke¹, Lisen Lin, Hong Liang, Xian Chen, Chao Han, Juan Li, Huang-Hao Yang

Affiliation

¹ The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350002, P. R. China. lijuanfzu@gmail.com.

PMID: 25786907
DOI: 10.1039/c5cc01129a

Abstract

In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adsorption
Animals
Biosensing Techniques / methods*
Cattle
Cell Survival
Intracellular Space / metabolism*
MCF-7 Cells
Nanoparticles*
Phototherapy / methods*
Polymers / chemistry*
Polymers / therapeutic use*
Pyrroles / chemistry*
Pyrroles / therapeutic use*
RNA, Messenger / metabolism
Serum Albumin, Bovine / chemistry*

Substances

Polymers
Pyrroles
RNA, Messenger
Serum Albumin, Bovine
polypyrrole