CNS injury: IL-33 sounds the alarm

Simmie L Foster; Sébastien Talbot; Clifford J Woolf

doi:10.1016/j.immuni.2015.02.019

CNS injury: IL-33 sounds the alarm

Immunity. 2015 Mar 17;42(3):403-5. doi: 10.1016/j.immuni.2015.02.019.

Authors

Simmie L Foster¹, Sébastien Talbot¹, Clifford J Woolf²

Affiliations

¹ FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
² FM Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: clifford.woolf@childrens.harvard.edu.

PMID: 25786172
DOI: 10.1016/j.immuni.2015.02.019

Abstract

Central nervous system trauma induces marked inflammation that has beneficial and deleterious consequences. In a recent issue of Neuron, Gadani et al. (2015) show that injured spinal cord releases the alarmin IL-33 to drive chemokines that recruit monocytes and promote recovery.

Publication types

Comment

MeSH terms

Animals
Central Nervous System Diseases*
Female
Gene Expression Regulation / physiology*
Interleukins / metabolism*
Male
Neuroglia / metabolism*
Recovery of Function / physiology*

Substances

Interleukins