Infected cells call their killers to the scene of the crime

Lalit K Beura; David Masopust

doi:10.1016/j.immuni.2015.03.001

Infected cells call their killers to the scene of the crime

Immunity. 2015 Mar 17;42(3):399-401. doi: 10.1016/j.immuni.2015.03.001.

Authors

Lalit K Beura¹, David Masopust²

Affiliations

¹ Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
² Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: masopust@umn.edu.

PMID: 25786170
DOI: 10.1016/j.immuni.2015.03.001

Abstract

Effector CD8(+) T cells scan tissues to locate and kill infected host cells. In this issue of Immunity, Hickman et al. (2015) show that the exploration is not random: infected monocytes attract their assassins by secreting chemokines, which accelerates clearance of epicutaneous vaccinia virus infection.

Publication types

Comment

MeSH terms

Animals
Female
Humans
Keratinocytes / immunology*
Poxviridae Infections / immunology*
Receptors, CXCR3 / immunology*
Skin / immunology*
T-Lymphocytes, Cytotoxic / immunology*
Vaccinia virus / immunology*

Substances

Cxcr3 protein, mouse
Receptors, CXCR3