Objectives: This study is to determine the levels of serum superoxide dismutase (SOD) and high sensitive C-reactive protein (hs-CRP) in type 2 diabetic patients with lower extremity vascular disease before and after interventional treatment.
Methods: A total of 65 patients were enrolled in this study, including 35 mails and 30 females. Another 65 healthy individuals were used as control, including 41 males and 24 females. Lesions and degrees of stenosis were determined by computed tomography angiography. Contralateral iliac artery and proximal femoral artery occlusion were treated by retrograde femoral artery puncture. The levels of serum SOD and hs-CRP were determined by enzyme-linked immunosorbent assay. Correlation was analyzed by Pearson's test. Progression-free survival curve was analyzed by Kaplan-Meier method.
Results: The levels of serum SOD at 20 min, 24 hr, 7 d, and 14 d after surgery were significantly decreased compared with those before surgery (P < 0.05). The levels of serum hs-CRP at 20 min and 24 hr after surgery were increased compared with those before surgery (P < 0.05). The level of serum hs-CRP at 14 d after surgery was significantly lower than that before surgery (P < 0.05). The correlation between SOD and hs-CRP was positive before surgery (r = 0.03, P < 0.001), but negative at 24 hr after surgery (r = -0.008, P < 0.001). The levels of serum SOD were significantly lower than median value (P < 0.05), while the Levels of serum hs-CRP were significantly higher than median value (P < 0.05).
Conclusions: The levels of serum SOD and hs-CRP were significantly different before and after interventional treatment. The levels of serum SOD and hs-CRP can be used as indicators for the efficacy and prognosis of interventional treatment on type 2 diabetic patients with lower extremity vascular disease.
Keywords: Type 2 diabetes; high sensitivity C-reactive protein; interventional treatment; lower extremity vascular disease; superoxide dismutase.