Abstract
While individually inefficient against Gram-negative bacteria, in-vitro combinations of rifampin and OAK were mutually synergistic since sub-minimal inhibitory concentrations of one compound have potentiated the other by 2-4 orders of magnitude. Synergy persisted in-vivo as single-dose systemic treatment of Klebsiella infected mice resulted in 10-20% versus 60% survival, respectively accomplished by individual and combined compounds. This outcome was achieved without drug formulation, rather, pharmacokinetic considerations have inspired the therapeutic regimen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Drug Synergism
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Gram-Negative Bacteria / drug effects*
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Gram-Positive Bacterial Infections / drug therapy
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Gram-Positive Bacterial Infections / microbiology
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Gram-Positive Bacterial Infections / veterinary
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Klebsiella / drug effects
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Male
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Mice
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Mice, Inbred ICR
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Microbial Sensitivity Tests
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Oligopeptides / chemical synthesis
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Oligopeptides / pharmacology*
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Oligopeptides / therapeutic use
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Rifampin / pharmacology*
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Rifampin / therapeutic use
Substances
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Anti-Bacterial Agents
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Oligopeptides
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Rifampin