Abstract
We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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DNA / chemistry
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DNA / metabolism*
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Electrophoretic Mobility Shift Assay
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Fluorescence Polarization
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Molecular Sequence Data
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Oligonucleotides
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Peptides / chemistry
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Peptides / metabolism*
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Protein Structure, Tertiary
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Proto-Oncogene Proteins c-jun / chemistry
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Proto-Oncogene Proteins c-jun / metabolism*
Substances
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Oligonucleotides
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Peptides
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Proto-Oncogene Proteins c-jun
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DNA