Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

Org Biomol Chem. 2015 May 21;13(19):5385-90. doi: 10.1039/c5ob00318k.

Abstract

We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA / chemistry
  • DNA / metabolism*
  • Electrophoretic Mobility Shift Assay
  • Fluorescence Polarization
  • Molecular Sequence Data
  • Oligonucleotides
  • Peptides / chemistry
  • Peptides / metabolism*
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-jun / chemistry
  • Proto-Oncogene Proteins c-jun / metabolism*

Substances

  • Oligonucleotides
  • Peptides
  • Proto-Oncogene Proteins c-jun
  • DNA