Association of four CpG-SNPs in the vascular-related genes with coronary heart disease

Leiting Xu; Xiaoying Chen; Huadan Ye; Qingxiao Hong; Mingqing Xu; Shiwei Duan

doi:10.1016/j.biopha.2015.01.014

Association of four CpG-SNPs in the vascular-related genes with coronary heart disease

Biomed Pharmacother. 2015 Mar:70:80-3. doi: 10.1016/j.biopha.2015.01.014. Epub 2015 Jan 12.

Authors

Leiting Xu¹, Xiaoying Chen¹, Huadan Ye¹, Qingxiao Hong¹, Mingqing Xu², Shiwei Duan³

Affiliations

¹ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, 315211 Zhejiang, PR China.
² Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, PR China.
³ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, 315211 Zhejiang, PR China. Electronic address: duanshiwei@nbu.edu.cn.

PMID: 25776483
DOI: 10.1016/j.biopha.2015.01.014

Abstract

Vascular-related gene polymorphism can affect the susceptibility of coronary heart disease. In current study, we aimed to evaluate the contribution of four vascular-related gene CpG-SNPs to coronary heart disease (CHD). A total of 784 angiography-proven CHD patients and 746 non-CHD controls were included in the current association study. The four CpG-SNPs (including VEGFA rs1005230, ACE rs4316, CST3 rs3827143 and AGTR1 rs275653) were genotyped using the Sequenom MassARRAY platform. All genotype distribution of four SNPs met HWE. Among the four CpG-SNPs, none was found to be associated with CHD on both genotype and allele levels. Further subgroup tests by age or gender were unable to observe any significant associations of them with CHD. Our case-control study showed that none of four CpG-SNPs in the vascular-related genes was associated with the risk of CHD in Han Chinese, although we could not exclude other genetic variants of these vascular-related genes with contribution to CHD.

Keywords: Coronary heart disease; CpG-SNPs; Polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Coronary Disease / genetics
Coronary Disease / metabolism*
CpG Islands / genetics*
Female
Gene Expression Regulation
Genetic Predisposition to Disease*
Genotype
Humans
Male
Polymorphism, Single Nucleotide*