Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus

Int J Mol Sci. 2015 Mar 12;16(3):5779-88. doi: 10.3390/ijms16035779.

Abstract

Dental implants are widely used and are a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss and a loss of integration. Stress concentrations may be diminished using a mechanobiologically integrated implant with bone tissue. The purpose of this study was to investigate the biomechanical behavior, biocompatibility and bioactivity of a Ti-Nb-Sn alloy as a dental implant material. It was compared with cpTi. Cell proliferation and alkaline phosphatase (ALP) activity were quantified. To assess the degree of osseointegration, a push-in test was carried out. Cell proliferation and ALP activity in the cells grown on prepared surfaces were similar for the Ti-Nb-Sn alloy and for cpTi in all the experiments. A comparison between the Ti-Nb-Sn alloy implant and the cpTi implant revealed that no significant difference was apparent for the push-in test values. These results suggest that implants fabricated using Ti-Nb-Sn have a similar biological potential as cpTi and are capable of excellent osseointegration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alloys / chemistry*
  • Alloys / pharmacology
  • Animals
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Cell Line
  • Cell Proliferation / drug effects
  • Elastic Modulus
  • Hydrophobic and Hydrophilic Interactions
  • Male
  • Mice
  • Niobium / chemistry
  • Prostheses and Implants
  • Rats
  • Rats, Sprague-Dawley
  • Surface Properties
  • Tin / chemistry
  • Titanium / chemistry

Substances

  • Alloys
  • Biocompatible Materials
  • Niobium
  • Tin
  • Titanium