Poly(ADP-ribose)--a unique natural polymer structural features, biological role and approaches to the chemical synthesis

Nucleosides Nucleotides Nucleic Acids. 2015;34(4):258-76. doi: 10.1080/15257770.2014.984073.

Abstract

Poly(ADP-ribose) (PAR) is a natural polymer, taking part in numerous important cellular processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of them, poly(ADP-ribose)polymerase-1 (PARP-1) is considered to be a perspective target for the design of new drugs, affecting PAR metabolism. The structure of PAR was established by enzymatic hydrolysis and further analysis of the products, but total chemical synthesis of PAR hasn't been described yet. Several approaches have been developed on the way to chemical synthesis of this unique biopolymer.

Keywords: DNA alkylation; bioconjugates; enzyme inhibition; modified nucleosides; nucleic acid biosynthesis; nucleotide excision and repair.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Biological Products*
  • Biopolymers*
  • Biosynthetic Pathways
  • Clinical Trials as Topic
  • Humans
  • Molecular Structure
  • Poly Adenosine Diphosphate Ribose / chemical synthesis
  • Poly Adenosine Diphosphate Ribose / chemistry*
  • Poly Adenosine Diphosphate Ribose / metabolism*
  • Poly(ADP-ribose) Polymerase Inhibitors / chemistry
  • Poly(ADP-ribose) Polymerase Inhibitors / pharmacology
  • Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use
  • Poly(ADP-ribose) Polymerases / chemistry
  • Poly(ADP-ribose) Polymerases / metabolism
  • Protein Binding
  • Static Electricity

Substances

  • Biological Products
  • Biopolymers
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Poly Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases