C. elegans as a tool for in vivo nanoparticle assessment

L Gonzalez-Moragas; A Roig; A Laromaine

doi:10.1016/j.cis.2015.02.001

C. elegans as a tool for in vivo nanoparticle assessment

Adv Colloid Interface Sci. 2015 May:219:10-26. doi: 10.1016/j.cis.2015.02.001. Epub 2015 Feb 15.

Authors

L Gonzalez-Moragas¹, A Roig¹, A Laromaine²

Affiliations

¹ Institut de Ciència de Materials de Barcelona, Campus UAB, 08193 Bellaterra, Spain.
² Institut de Ciència de Materials de Barcelona, Campus UAB, 08193 Bellaterra, Spain. Electronic address: alaromaine@icmab.es.

PMID: 25772622
DOI: 10.1016/j.cis.2015.02.001

Abstract

Characterization of the in vivo behavior of nanomaterials aims to optimize their design, to determine their biological effects, and to validate their application. The characteristics of the model organism Caenorhabditis elegans (C. elegans) advocate this 1mm long nematode as an ideal living system for the primary screening of engineered nanoparticles in a standard synthetic laboratory. This review describes some practicalities and advantages of working with C. elegans that will be of interest for chemists and materials scientists who would like to enter the "worm" community, anticipates some drawbacks, and offers relevant examples of nanoparticle assessment by using C. elegans.

Keywords: Caenorhabditis elegans; Model organism; Nanoparticles; Nanoscience and nano-bio interfaces.

Publication types

Review