MicroRNA-21 expression and susceptibility to HPV-induced carcinogenesis - role of microenvironment in K14-HPV16 mice model

Isabel Paiva; Rui M Gil da Costa; Joana Ribeiro; Hugo Sousa; Margarida M S M Bastos; Ana Faustino-Rocha; Carlos Lopes; Paula A Oliveira; Rui Medeiros

doi:10.1016/j.lfs.2015.02.020

MicroRNA-21 expression and susceptibility to HPV-induced carcinogenesis - role of microenvironment in K14-HPV16 mice model

Life Sci. 2015 May 1:128:8-14. doi: 10.1016/j.lfs.2015.02.020. Epub 2015 Mar 12.

Authors

Isabel Paiva¹, Rui M Gil da Costa², Joana Ribeiro³, Hugo Sousa³, Margarida M S M Bastos⁴, Ana Faustino-Rocha⁵, Carlos Lopes⁶, Paula A Oliveira⁷, Rui Medeiros⁸

Affiliations

¹ Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
² LEPABE, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal; Experimental Pathology and Therapeutics Group, CI-IPOP, Portuguese Institute of Oncology, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
³ Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; Virology Service, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
⁴ LEPABE, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal.
⁵ Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, 5001-911 Vila Real, Portugal.
⁶ Experimental Pathology and Therapeutics Group, CI-IPOP, Portuguese Institute of Oncology, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
⁷ Veterinary Sciences Department, University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, 5001-801 Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, UTAD, Quinta de Prados, 5001-911 Vila Real, Portugal.
⁸ Molecular Oncology and Viral Pathology Group, CI-IPOP, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal; Virology Service, Portuguese Institute of Oncology of Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal; CEBIMED, Faculty of Health Sciences of Fernando Pessoa University, Porto, Portugal; Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro - Núcleo Regional do Norte), Estrada Interior da Circunvalação, no. 6657, 4200-177 Porto, Portugal. Electronic address: ruimedei@ipoporto.min-saude.pt.

PMID: 25771247
DOI: 10.1016/j.lfs.2015.02.020

No abstract available

Keywords: Hyperplasia; In situ carcinoma; K14-HPV16; Microenvironment; miR-21.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Female
Gene Expression
Human papillomavirus 16 / immunology*
Hyperplasia / metabolism
Hyperplasia / virology
Mice, Transgenic
MicroRNAs / genetics
MicroRNAs / metabolism*
Papillomavirus Infections / genetics
Papillomavirus Infections / immunology
Papillomavirus Infections / metabolism*
Papillomavirus Infections / virology
Skin / metabolism
Skin / pathology
Skin / virology
Skin Neoplasms / genetics
Skin Neoplasms / immunology
Skin Neoplasms / metabolism*
Skin Neoplasms / virology

Substances

MIRN21 microRNA, mouse
MicroRNAs