Trinorcassane and cassane diterpenoids from the seeds of Caesalpinia minax

Yong Zheng; Shu-Wei Zhang; Li-Jiang Xuan

doi:10.1016/j.fitote.2015.03.006

Trinorcassane and cassane diterpenoids from the seeds of Caesalpinia minax

Fitoterapia. 2015 Apr:102:177-81. doi: 10.1016/j.fitote.2015.03.006. Epub 2015 Mar 11.

Authors

Yong Zheng¹, Shu-Wei Zhang¹, Li-Jiang Xuan²

Affiliations

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China.
² State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China. Electronic address: ljxuan@mail.shcnc.ac.cn.

PMID: 25771123
DOI: 10.1016/j.fitote.2015.03.006

Abstract

An unprecedented trinorcassane diterpenoid and a cassane furanoditerpenoid were isolated from the seeds of Caesalpinia minax. It is the first example of dicylic cassane-type trinorditerpenoid, which is different from reported 16- or 17-norcassane diterpenoids. The structure of the compounds was elucidated on the basis of 1D and 2D NMR analysis. Biosynthesis pathways are postulated, and this pathway was supported by semi-synthesis.

Keywords: Caesalpinia minax Hance; Diterpenoids; Norcassane.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosynthetic Pathways
Caesalpinia / chemistry*
Diterpenes / chemistry*
Diterpenes / isolation & purification
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts / chemistry
Seeds / chemistry*

Substances

Diterpenes
Plant Extracts
trinorcassane