Three pairs of diastereoisomeric flavanone glycosides from Viscum articulatum

Fitoterapia. 2015 Apr:102:156-62. doi: 10.1016/j.fitote.2015.03.009. Epub 2015 Mar 11.

Abstract

Phytochemical examination of the leaves and stems of Viscum articulatum resulted in the isolation of three pairs of new flavanone glycosides, 2R/2S-viscarticulide A-C (1a/1b-3a/3b), together with eight known compounds (7-14). Their structures were established by extensive spectroscopic data analyses. The diastereoisomers were separated by HPLC on a chiral phase and the absolute configuration at C-2 was determined by circular dichroism (CD) spectra. The protective effects of compounds 1-3 against H2O2-induced cytotoxicity with EA.hy926 cells were tested. The results showed that compounds 1-3 improved the survival of EA.hy926 cells after H2O2 exposure at the tested concentrations.

Keywords: Circular dichroism; Cytoprotection; Diastereoisomers; Flavanone glycosides; Viscum articulatum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Flavanones / chemistry*
  • Flavanones / isolation & purification
  • Flavones / chemistry
  • Flavones / isolation & purification
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Humans
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Viscum / chemistry*

Substances

  • Flavanones
  • Flavones
  • Glycosides
  • Plant Extracts
  • viscarticulide A
  • viscarticulide B
  • viscarticulide C